Review on the Biomedical Importance of Taurine

Review on the Biomedical Importance of taurineM.K.Vanitha, K. Baskaran, K.Periyasamy, D.Saravanan, A.Ilakkia, S.Selvaraj, R.Venkateswari, B.Revathi Mani, P.Anandakumar, D. SakthisekaranABSTRACTObjectives To briefly outline the substances of taurine on assorted organs, in order to elucidate the biomedical importance of taurine. Summary taurineis a sulfur-containing aminic window glass that is put in in mammalian wavers.taurinehas different biologic and physiological functions. It is a comp cardinalnt of insolence red-hots, which are habitd to protagonist absorb fats and fat-soluble vitamins. It in like manner helps regulate the trick out marrowbeat, maintain stallular phone membrane constancy and prevent brain cell over-activity. In addition,taurine chloramine, an endogenous product derived from emotional neutrophils, has been account to suppress obesity-induced oxidative stress and inflammation in adipocytes. consequence This review is an attempt to reveal the bio medical importance of taurine including its effect on heart, lung, kidney, bone, fetal tissue, retinal photoceptors, oxidative stress and cancer.Key actors linetaurine, endothelium, lung, kidney, antioxidant1. INTRODUCTIONtaurine originated from the Latin word taurus, which means bull or ox, as it was first isolated from ox insolence in 1827 by Austrian scientists Friedrich Tiedemann and Leopold Gmelin.1 It is often considered an aminic venereal disorder in scientific literatures. It is a vital nutrient for cats, and probably also for primates, since it is natural for the bafflement and choice of neural cell.2 In healthy humans, dietary foodstuffs are the main sources of taurine. exalted dousings of taurine are entrap in animal sources whilst undetectable in vegetables.3 enrol 1 Structure of taurineSince vegetarians have no dietary intake of taurine and often eat crushed sulphur amino acid diets, plasma concentrations are freeze off in vegetarians.Methionine and cyst eine are precursors of taurine, tho synthesis ability varies widely amongst species, the maximal human synthesis locate is unk nowadaysn. The average daily synthesis in braggys ranges between 0.4 1.0 mmol (50-125 mg) 4 beneath stress the synthesis capacity may be impaired therewith some authors consider taurine as a conditionally essential amino acid, whereas for former(a)s it remains non essential. Fish is a good source of taurine and tests for taurine content for a variety of fish have been conducted.Figure 2 Biosynthesis of taurine2. CHEMISTRY OF taurineThe molecular prescript of taurine is C2H7NO3S and its molecular weight is 125.15. It has a pKa of 1.5 (at 25 C) and a run point of 300 C (decomposition) and shows a bulk density of 0.650.75g/cm3 and a density of approximately 1.7g/cm3. It is soluble in peeing (10 g dissolves in 100 mL at 25 C) and insoluble in ethanol, ethyl radical ether and acetone. The pH of a 5 % solution in water is 4.1 5.6. Taurine is a white cry stalline powder that is almost scentless that with a slightly acidic taste. It contains by specification at least 98.0 % taurine in dried substance. Taurine is a monobasic acid that has unique physical constants compared to opposite neuroactive amino acids. The uniqueness of taurine is principally callable to the functional group containing sulfur, the sulfonic group, unlike the carboxylic group exemplary of all the other natural amino acids. This difference may provide the rationale behind the unique biological nature of taurine which is non shared with other neuroactive amino acids. With its sulfonate group, it is a stronger acid (pKa 1.5) than glycine, aspartic acid, -alanine, and -aminobutyric acid (GABA). correspondently, having a pKb value of 8.82, it is less basic than GABA, -alanine and glycine. Its solubility in water is 10.48g/100mL at 258C, which is lower than that of -alanine, GABA or glycine.Table 1 Properties of taurine3. biomedical IMPORTANCE OF taurine3.1 ta urine IN FETAL DEVELOPMENT AND neonatal GROWTHThe human fetus has no ability to synthesize taurine, but considerably uplifted levels of taurine have been recorded, and this may be due to a very efficient placental role of taurine in disease prevention. The amount of taurine was found to be very graduate(prenominal) in human breast milk compared to cows milk, on which a large portion of infants are fed, and this may be due to the high concentration of taurine in placenta. Thus, taurine is now added to some infant formulas to provide improved nourishment.5 Several types of organ dysfunction develop from abnormalities of taurine levels in growing children. In neonatal cardiomyocytes (as in adult ones), taurine functions as an organic osmolyte. During pregnancy, taurine accumulates in the maternal tissues, from where it is periodically released to the fetus via the placenta. In infants, taurine is acquired through the mothers milk. This is the coiffe when taurine accumulates more(p renominal) in fetal and neonatal brain. A low maternal taurine concentration will lead to low fetal taurine concentration.63.2 TAURINE AND THE CENTRAL NERVOUS arrangement (CNS)Taurine is the most abundant amino acid in the brain after glutamate, and it is found in all cell types in the CNS. A high concentration of taurine occurs in the developing brain, but with maturity, its levels fall to 30%.7 Taurine is extensively involved in neurological activities, including protection, modulation of neural excitability, sustenance of cerebellar functions and modulation of motor behavior through interaction with dopaminergic, adrenergic, serotonergic and cholinergic receptors and through glutamate.8 Free radicals are particularly detrimental to brain tissue where there is a high concentration of lipids, suitable orchestrate for oxidation. Taurine is now being explored for its capacity to protect tissues against oxidative stress. In cerebellar neurons, stimulation by excitatory agents was e ffectively countered by taurine. While taurine may not directly decrease the levels of discontinue radicals, it does increase cell viability. This may become an important alternate protective mechanism against free radical damage to brain cells.3.3 TAURINE AND THE LIVERLiver synthesizes bile, which is a mixture of bile acids, salts, bilirubin, cholesterol and fatty acids, stored in the gallbladder. It is also trusty for the detoxification of harmful substances, but only if available in sufficient quantities. The bile acids act as detergents to solubilize or emulsify food into digestible components. This detergent action is due to the presence of two lipophilic and hydrophilic ends in the bile acids. The hydrophilic regions include sulfonates or carboxylate backbones. Mammals mainly use taurine and, to a lesser extent glycine, as the major amino acids that conjugate with bile acids to form biliary salts. Among the tauro-conjugates, taurocholic acid (TC), taurodeoxycholic acid (T DC), taurolithocholic acid (TLC), and taurocheno- deoxycholic acid (TCDC), can act as cholagogues (agents that promote the flow of bile into the intestine) or choleretics (agents that stimulate the liver to increase exertion of bile). The ratio between tauro-conjugates and glycocholate in humans is about 3 1 and this ratio is adversely affected in cases of low taurine supply. In the absence of TC, bile salts can precipitate and form gallstones.93.4 TAURINE AND HYPERCHOLESTEROLEMIAIn blood, cholesterol is carried in low density lipoproteins ( low-density lipoprotein) and high density lipoproteins (HDL). Elevated LDL levels are implicated in a range of heart and vascular diseases, including myocardial infarction (heart attack) and atherosclerosis (clogging of the arteries). Taurine can attenuate the increase levels in total and LDL cholesterol in animals consuming a high fat, high cholesterol diet.10 High fat diets produce hypercholesterolemia, atherosclerosis, and compendium of li pids on the aortic valve of the heart. Dietary taurine supplements are known to be full in situations when the body cholesterol status is high, as closely as normal. In particular, it has been show that taurine is capable of reducing plasma lipid concentration and visceral fat in diabetic rats as well as in obese humans.113.5 TAURINE AND OCCUPATIONAL environmental LIVER DAMAGEExposure to toxic chemicals, which is a common guess for industrial workers, has been linked to birth defects, sterility, headache, chronic fatigue, arthritic-like inflammation and many other symptoms. These chemicals have a deleterious effect on the liver and taurine is able to moderate the extent and severity of their side. Furthermore, it reduces the number of cancer antigen-positive hepatocytes and in several cases of chemical moving-picture show, taurine also protected against DNA damage.123.6 TAURINE AND DIABETESType II diabetes mellitus is one of the most common human diseases and its prevalence is constantly growing. This pathology is characterized by the reduced sensitivity of the cellular targets, mainly adipose and muscle cells, to insulin stimulation. Such alteration can lead to insulin resistance, hyper-insulinemia, hyperglycemia, and several other metabolic dysfunctions. Lifestyle, dietary habits, and environment can influence the appearance of diabetes.13 Taurine supplements administered to patients with type 2 diabetes were turn up to be beneficial. Also, taurine alleviates clinical complications of diabetes, having beneficial set up on nephropathy and retinopathy. In animal models of experimental insulin resistance, it has been demonstrated that the metabolic alterations associated with diabetes are ameliorated by taurine administration.143.7 TAURINE AND THE CARDIOVASCULAR SYSTEMTaurine concentration is found to be high in the mammalian heart. The maintenance of cardiac taurine content is governed by a serial publication of processes, which include transport, accum ulation, binding, release, as well as metabolism. The availability of taurine in cardiac tissue is generally dependent on the transport process, because of its exceptional ability to be effectively synthesized in the cardiac tissue. Taurine deprivation may possibly be linked to cardiomyopathy, as it has been well reported in cats. Furthermore, conclusive evidence of the relationship between taurine and heart health was provided by studies with transgenic mice knocked out of its taurine transporter.153.8 TAURINE AND ENDOTHELIAL dysfunctionEndothelial dysfunction is common among cardiovascular diseases and diabetes and it is known as one of the primary events in the development of atherosclerosis and diabetic angiopathies.16 Taurine has been shown to be a protector of endothelial body structure and function after film to inflammatory cells, their mediators, or other chemicals. Treatment of activated macrophages with taurine inhibits the multiplication of NO and other inflammator y mediators, which is present in high amounts in inflammatory cells, seems to be uniquely capable of modifying homeostasis in both target and receptor cells through antioxidant calcium flux and the osmo regulatory pathway. Finally, taurine was proven to protect endothelial cells from damage induced by hyperglycemia and oxidise LDL.173.9 TAURINE AND LUNG FUNCTIONThe depletion of taurine is particularly harmful to pulmonic tissue. dental consonant macrophages, which reside on the surface of lung alveoli, ingest inhaled particulates to clear the dental spaces. However, alveolar macrophages, much like the general macrophages, become more susceptible to ROS and more pro-inflammatory when deprived of the antioxidant protective capacity that taurine provides. Fibrosis may also result from toxic chemical exposure. There are numerous factors liable for toxin-induced damage to lung cells and tissue in animal models of induced interstitial pulmonary fibrosis. In several cases, the administ ration of taurine, niacin or a confederacy of both, yielded promising results, and can reverse increased lung lipid peroxidation. Furthermore, the ability to cleanse ROS and to stabilize cell membranes contributed to the suppression of lung collagen accumulation and oxidative stress damage. asthma attack is a chronic disease characterized by bronchial obstruction and respiratory tract hyper reactivity with neutrophil accumulation. There is increasing evidence that excessive production of ROS along with defective endogenous antioxidant defense mechanisms may be responsible for asthma. In an animal model of allergic asthma, taurine content was found to be reduced and oral treatment with taurine produced anti-inflammatory responses. Similar personal effects have also been demonstrated in humans.183.10 TAURINE AND THE KIDNEYIn the kidneys, taurine is found at a high concentration, which is regulated by the reabsorption at the modulating proximal tubule according to its dietary inta ke. In alleviating the diabetic nephropathy, taurine serves as an osmolyte, an endogenous antioxidant and an inhibitor of phosphokinase C (PKC) in mesangial cells. The beneficial effects of taurine may be due to its well-known anti-oxidative, anti-inflammatory and anti-apoptotic activities.193.11 TAURINE AND RETINAL PHOTORECEPTOR ACTIVITYThe common eye disease cataract demonstrates the importance of lens condition. It is speculated that cataract formation may be largely due to the oxidation of protein in the lens. Consequently, a lack of antioxidants could be a major factor in the development of cataracts. Since taurine acts as an antioxidant directly, it prevents changes in the levels of glutathione, ATP and insoluble proteins, molecular factors that predispose to cataract formation.20 Furthermore, taurine plays a critical role in the structure and function of the photoreceptors, specifically rods, which are responsible for seeing in both low illumination and night conditions. The promotional effect of taurine in cellular regeneration is compromised with drugs that induce the activation of PKC or phosphate inhibitors.21 Retinitis pigmentosa (RP) is characterized by visual field loss and night blindness. Nutritional factors are now recognized as important factors in the reversal of RP. Experimental conclusion suggests that RP patients recover their visual capacities with the addition of nutrients, including taurine, which has been found to be beneficial. Taurine and zinc interact with each other to influence the development of the retinal structure and function in the eye. Both molecules promote the healthy oscillatory potentials inevitable for vision. Deficiency of taurine has been identified as the cause of all these diseases and clearly demonstrates its vital role in vision.223.12 TAURINE IN BONE waver FORMATION AND INHIBITION OF BONE LOSSBone tissue contains cells and the extracellular matrix, which is composed of collagen fibers and noncollagenous p roteins. In bone tissue, taurine is found in high concentration, similar to that found in the liver and kidneys. This taurine-bone interaction is one of the a la mode(p) added to its long list of actions.23 In bones, taurine acts as a picture agent. It is involved in both bone formation and inhibition of bone loss. In addition to these two major actions, taurine has beneficial effects in wound healing and bone repair.3.13 ANTICANCER ACTIVITY OF TAURINETaurine has been found that taurine has radio protective properties and anti-mutagenic effect, reducing nucleic acid damage. The chemo-preventive activity of taurine and, in particular, 1-(2-chloroethyl)- 3(2-dimethyl sulfony) ethyl-11-nitrosourea derivative (e.g., tauromustine), have been used against colon and hepatic cancers. In hepato-carcinogenesis, the degree of membrane damage and the fall in glutathione function were reduced when oral taurine was given prior to exposure to carcinogens. These findings suggest that taurine, by i nhibiting lipo-peroxidation and preserving the glutathione antioxidant system, offers protection against membrane breakdown.24Recombinant interleukin-2 immunotherapy is utilized as a therapeutic approach in certain types of cancers. However, it may produce a cytotoxic effect on both tumor cells and healthy vascular endothelial cells. In such cancer therapy programs, taurine reduces interleukin endothelial cell cytotoxicity without compromising the antitumor activity of the immunotherapy. In addition, when taurine is used in conjunction with interleukin, it actually increases the tumor cytotoxicity. For the treatment of intra peritoneal (abdominal) tumors, researchers have study a taurine derivative, taurolidine, as both an alternative and an adjunct to heparin, a standard substance used to prolong the clotting time of blood. In certain cancers, the amino acid profile yields data about the disease that is useful to better assess the therapeutic approach. Colorectal cancer patients register a characteristic amino acid profile with significantly lower intracellular levels of taurine, glutamic acid, methionine, and ornithine and elevated levels of valine. Likewise, squamous cell carcinoma of the head and neck exhibit a profile that is marked by decreased taurine.254. CONCLUSIONThis review highlights the divergent effects of taurine on different tissues. Thus, further studies on taurine could exemplify the beneficial role of taurine in human health and disease.1